RE9 Blood Lab Puzzle: Microscope Analysis Sequence Explained

The Blood Lab puzzle is one of the mandatory puzzles in Resident Evil Requiem. You’ll need to use a laser microscope to analyze blood specimens by solving a block-flipping logic puzzle. It sounds complicated, but once you know the sequence, it takes about ten seconds.

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Blood Lab Location

Where it is: East Wing of Rhodes Hill Chronic Care Center

How to get there:

1. From the main hall, head to the East Wing
2. Pass through the waiting room
3. Enter the Blood Lab

Heads up: The East Wing has enemies. Come prepared.

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Blood Specimen Types

Reversible Blood Specimen

• Availability: All difficulty levels
• Location: On the lab table or nearby in the Blood Lab
• Required for: Main story progression

Polymerized Blood Specimen

• Availability: Insanity difficulty only
• Location: Closet behind the Level 1 locked door near the waiting room
• How to access:
  1. Find the Level 1 door near the waiting room
  2. Unlock it with the appropriate key or code
  3. The specimen is in the closet inside

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How the Microscope Puzzle Works

The microscope shows a grid of colored blocks. The mechanic is similar to the classic “Lights Out” puzzle:

• Clicking a block changes that block and all adjacent blocks
• The goal is to get all blocks to the same color
• Order matters — you need the right sequence

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Solutions

Reversible Blood Specimen Solution

Click order:

1. Bottom-left block
2. Center block
3. Top-right block
4. Second block from the top

Step-by-step:

1. Place the Reversible specimen in the microscope
2. Activate the microscope to enter analysis mode
3. Click the bottom-left block
4. Click the center block
5. Click the top-right block
6. Click the second block from the top
7. All blocks should now be the same color — puzzle solved

Polymerized Blood Specimen (Insanity Difficulty)

The Polymerized specimen uses the same underlying mechanic but with a more complex starting pattern. General approach:

1. Observe the initial block configuration
2. Start from the corners — they affect fewer adjacent blocks
3. Work row by row toward the center
4. Adjust as needed based on what changes

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Puzzle Mechanics Deep Dive

Why This Works

The Blood Lab puzzle is a variant of the “Lights Out” logic puzzle:

• Each click affects a cross-shaped area (the clicked block + its four neighbors)
• The key insight: the order of clicks matters
• The provided sequence is the optimal solution for the Reversible specimen’s starting configuration

General Strategy (If You Want to Solve It Yourself)

1. Note the starting state — take a screenshot or sketch it
2. Start with corners — corner blocks have fewer neighbors, giving you more control
3. Work row by row — solve the top row, then use it as a reference for the next
4. Don’t panic — you can always reset and try again

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Getting to the Blood Lab

Route from Main Hall

Main Hall
    ↓
East Wing corridor
    ↓
Waiting Room
    ↓
Blood Lab

Before You Go

• Bring ammo: Enemies patrol the East Wing
• Check your inventory: Make sure you have space for the specimen
• Save first: Use the nearest typewriter before tackling the puzzle area

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After Solving the Puzzle

What Happens Next

Completing the Blood Lab puzzle:

• Advances the main story
• Reveals critical information about “The Girl”
• Unlocks access to new areas
• Provides key items for later sections

Story Significance

The blood analysis results are central to Grace’s storyline — they explain the nature of the infection and hint at the truth behind the events at Rhodes Hill. Don’t skip the cutscene.

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Quick Reference

Specimen	Click Order
Reversible (all difficulties)	Bottom-left → Center → Top-right → 2nd from top
Polymerized (Insanity only)	Work from corners inward, row by row

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Wrapping Up

The Blood Lab microscope puzzle is one of those RE puzzles that looks intimidating until you know the answer — then it’s trivial. Four clicks in the right order and you’re done. If you’re on Insanity difficulty, the Polymerized specimen adds a bit more challenge, but the same logical approach applies. Now go solve it and find out what’s really going on with “The Girl.”