Slay the Spire 2: All Monsters & Boss Guide - Complete Data & Strategies

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This guide covers all 85 monster encounters in Slay the Spire 2 (data version v0.102.0), organized by act and zone. Bosses include full HP data, elite encounters are listed with strategies, and normal/weak encounters are compiled in reference tables.

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Table of Contents

1. Act 1 - Overgrowth: Bosses
2. Act 1 - Overgrowth: Elites & Normal Encounters
3. Act 1 - Underdocks: Bosses
4. Act 1 - Underdocks: Elites & Normal Encounters
5. Act 2 - Hive: Bosses
6. Act 2 - Hive: Elites & Normal Encounters
7. Act 3 - Glory: Bosses
8. Act 3 - Glory: Elites & Normal Encounters
9. General Boss Fighting Strategies

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Act 1 - Overgrowth Bosses

Act 1 Overgrowth has three possible boss encounters. You will face one per run.

Overgrowth Boss: Vantom

HP: 173 | Type: Boss

Vantom is the most approachable Act 1 boss. Its relatively low HP means most decks can close it out before its patterns become threatening. Focus on consistent damage and keep enough block for its stronger turns.

Overgrowth Boss: Ceremonial Beast

HP: 252 | Type: Boss

Ceremonial Beast is a solo boss with moderate HP. It has no minions to manage, so you can focus all damage on it directly. Bring Vulnerable application to amplify your damage output and keep block ready for its heavier hits.

Overgrowth Boss: The Kin

Kin Priest: 190 HP | Kin Follower ×2: 58–59 HP each | Type: Boss

This is a 3-enemy fight. The two Kin Followers accompany the Kin Priest and will attack every turn. AoE cards are extremely valuable here — clear the Followers first to reduce incoming damage, then focus the Priest. If your deck lacks AoE, target the Priest directly since the Followers have low HP and can be cleaned up quickly once the Priest falls.

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Act 1 - Overgrowth: Elites & Normal Encounters

Elite: Bygone Effigy

HP: 127 | Type: Elite

A solo elite with moderate HP. Prioritize burst damage to end the fight before it can build up threatening buffs.

Elite: Byrdonis

HP: 91–94 | Type: Elite

Byrdonis summons a Byrdpip (9999 HP — unkillable) during combat. Ignore the Byrdpip entirely and focus all damage on Byrdonis itself.

Elite: Phrog Parasite

HP: 61–64 | Type: Elite

Low HP for an elite. Aggressive decks can often burst this down in 2–3 turns before it becomes a threat.

Normal Encounters

Encounter	Monsters	HP
Cubex Construct	Cubex Construct	65
Fogmog	Fogmog	74
Overgrowth Flora	Flyconid, Snapping Jaxfruit	47–49 / 31–33
Shroom and Slime	Flyconid	47–49
Overgrowth Crawlers	Fuzzy Wurm Crawler, Shrinker Beetle	55–57 / 38–40
Inklets	Inklet ×3	11–17 each
Swarm of Slimes	Leaf Slime (M), Twig Slime (M)	32–35 / 26–28
Strangler and Friend	Leaf Slime (M), Leaf Slime (S), Slithering Strangler, Snapping Jaxfruit, Twig Slime (M), Twig Slime (S)	53–55 / 31–33 / 7–11
Mawler	Mawler	72
A Pair of Nibbits	Nibbit ×2	42–46 each

Weak Encounters

Encounter	Monsters	HP
Vine Shambler	Vine Shambler	61
Fuzzy Wurm Crawler	Fuzzy Wurm Crawler	55–57
Group of Slimes	Leaf Slime (M+S), Twig Slime (M+S)	7–11
A Lone Nibbit	Nibbit	42–46
Shrinker Beetle	Shrinker Beetle	38–40

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Act 1 - Underdocks Bosses

Act 1 Underdocks has three possible boss encounters. You will face one per run.

Underdocks Boss: Lagavulin Matriarch

HP: 222 | Type: Boss

Lagavulin Matriarch is a solo boss. Its 222 HP is manageable but it hits hard. Bring burst damage to end the fight quickly, and have a plan for deck bloat if it shuffles status cards into your deck.

Underdocks Boss: Soul Fysh

HP: 211 | Type: Boss

Soul Fysh is a solo boss with 211 HP. It interacts with your hand size — keep your hand lean and play cards efficiently each turn to minimize its damage scaling.

Underdocks Boss: Waterfall Giant

HP: 240 | Type: Boss

Waterfall Giant is a solo boss with 240 HP. It hits hard and rewards paced play — alternate between damage and block turns rather than going all-in every turn. Save burst damage for when you have a defensive turn planned to weather its retaliation.

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Act 1 - Underdocks: Elites & Normal Encounters

Elite: Phantasmal Gardeners

4× Phantasmal Gardener: 26–31 HP each | Type: Elite

Four low-HP enemies. AoE cards can clear this encounter in 1–2 turns. If you lack AoE, focus one at a time — their individual HP is low enough that single-target attacks still work fine.

Elite: Skulking Colony

HP: 74 | Type: Elite

A solo elite with low HP. Straightforward fight — deal damage and block its attacks.

Elite: Terror Eel

HP: 140 | Type: Elite

The toughest Underdocks elite. 140 HP means you need sustained damage. Watch for debuffs and keep your block up.

Normal Encounters

Encounter	Monsters	HP
Underdocks Wildlife	Calcified Cultist, Seapunk	38–41 / 44–46
Cultists	Calcified Cultist, Damp Cultist	38–41 / 51–53
Many Corpse Slugs	Corpse Slug ×3	25–27 each
Two Gremlins in a Trenchcoat	Gremlin Merc	47–49
Fossil Stalker	Fossil Stalker	51–53
Evil Gas	Living Fog	80
Haunted Ship	Haunted Ship	63
Punch Construct	Punch Construct	55
Sewer Clam	Sewer Clam	56
Two-Tailed Rats	Two-Tailed Rat ×3	17–21 each

Weak Encounters

Encounter	Monsters	HP
Corpse Slugs	Corpse Slug ×2	25–27 each
Seapunk	Seapunk	44–46
Sludge Spinner	Sludge Spinner	37–39
Toadpoles	Toadpole ×2	21–25 each

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Act 2 - Hive Bosses

Act 2 Hive has three possible boss encounters. You will face one per run.

Hive Boss: The Insatiable

HP: 321 | Type: Boss

The Insatiable features the Sandpit counter mechanic — it starts at 4 and decreases each turn. When it hits 0, you die instantly. Play Frantic Escape cards every turn to keep the counter up. These cards cost 0 energy and are added to your hand automatically. Prioritize survival and counter management over raw damage output.

Hive Boss: Knowledge Demon

HP: 379 | Type: Boss

Knowledge Demon is the highest-HP Act 2 boss at 379. Each turn it offers a Demonic Choice — pick one of three cards to add to your hand. Unplayed added cards deal damage at turn end, so always play what you pick. Energy management is critical; prioritize cards with immediate impact over multi-turn engines.

Hive Boss: Kaiser Crab

Crusher: 209 HP | Rocket: 199 HP | Type: Boss

Kaiser Crab is a two-claw fight — you never attack the main body. Kill Rocket (199 HP) first since its damage ignores block. Once Rocket is down, focus Crusher (209 HP). Don’t split damage between both claws; focus one target at a time to reduce incoming attacks as fast as possible.

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Act 2 - Hive: Elites & Normal Encounters

Elite: The Decimillipede

3 segments: 40–46 HP each | Type: Elite

Three segments with equal HP. AoE cards can clear all three quickly. If using single-target, focus the Front segment first to reduce its attacks.

Elite: Entomancer

HP: 145 | Type: Elite

Entomancer summons an Osty (1 HP) during combat. Ignore the Osty and focus all damage on Entomancer. The summon is a distraction — don’t waste attacks on it.

Elite: Infested Prism

HP: 200 | Type: Elite

A solo elite with 200 HP. The highest-HP Hive elite. Bring sustained damage and solid block to survive the extended fight.

Normal Encounters

Encounter	Monsters	HP
Bowlbug Swarm	Bowlbug (Rock) ×1 + 2 random	45–48
Slumber Party	Bowlbug (Rock), Bowlbug (Silk), Slumbering Beetle	45–48 / 40–43 / 86
Tunneling Twosome	Chomper, Tunneler	60–64 / 87
An Automaton Pair	Chomper ×2	60–64 each
Many Exoskeletons	Exoskeleton ×4	24–28 each
Hunter Killer	Hunter Killer	121
Louse Progenitor	Louse Progenitor	134–136
Mass of Mytes	Myte ×2	61–67 each
Ovicopter	Ovicopter	124–130
Spiny Toad	Spiny Toad	116–119
The Obscura	The Obscura	123

Weak Encounters

Encounter	Monsters	HP
Bowlbugs	Bowlbug (Rock)	45–48
Exoskeletons	Exoskeleton ×3	24–28 each
Thieving Hopper	Thieving Hopper	79
Tunneler	Tunneler	87

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Act 3 - Glory Bosses

Act 3 Glory has three possible boss encounters. You will face one per run.

Glory Boss: Test Subject

HP: Variable (multi-phase) | Type: Boss

Test Subject is a 3-phase fight. After each “death” it becomes invulnerable, heals, and changes mechanics.

• Phase 1: Gains Strength whenever you play a Skill — limit Skill usage
• Phase 2: Punishes Skills even harder, pivot to Attacks and Powers only
• Phase 3: Gains Intangible every other turn — use multi-hit attacks to maintain pressure during its defensive turns

Glory Boss: The Doormaker

The Doormaker is one of Act 3’s most imposing bosses with a massive 489 HP pool — the highest of any single-entity boss in the game.

Statistics:

• HP: 489
• Type: Boss (Glory)

Strategy: The Doormaker’s enormous HP demands sustained damage output over many turns. Decks that rely on short burst windows will struggle — prioritize scaling powers and consistent attack cards. Bring strong block generation to survive the extended fight, and use any Strength-amplifying relics or cards to accelerate your damage.

Glory Boss: Queen

Queen is a two-entity boss fight. You face both the Queen and her Torch Head Amalgam simultaneously.

Statistics:

• Queen: 400 HP
• Torch Head Amalgam: 199 HP
• Type: Boss (Glory)

Strategy: Decide early whether to focus the Torch Head Amalgam first (lower HP, removes one attacker) or pressure the Queen directly. AoE cards that hit both targets simultaneously are extremely efficient here. The combined HP pool of 599 makes this one of the longest boss fights in the game — ensure your deck has enough sustain and scaling to go the distance.

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Act 3 - Glory: Elite Encounters

Elite: Knight Gang

Three knights fight together — Flail Knight, Magi Knight, and Spectral Knight.

Monster	HP
Flail Knight	101
Magi Knight	82
Spectral Knight	93

AoE attacks are essential here. Focus the Magi Knight first to remove magical threats, then clean up the remaining two.

Elite: Mecha Knight

• HP: 300
• A heavily armored solo elite with high HP. Bring armor-piercing or multi-hit attacks to deal with its defenses efficiently.

Elite: Soul Nexus

• HP: 234
• A dangerous solo elite. Prioritize burst damage to end the fight quickly before its soul-based mechanics escalate.

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Act 3 - Glory: Normal Encounters

Encounter	Monsters	HP
Bot Buddies	Axebot ×2	40–44 each
Construct Menagerie	Cubex Construct ×2, Punch Construct	65 / 65 / 55
Fabricator	Fabricator	150
Frog Knight	Frog Knight	191
A Lone Globe Head	Globe Head	148
Owl Magistrate	Owl Magistrate	234
Many Scrolls of Biting	Scroll of Biting ×4	31–38 each
Slimed Berserker	Slimed Berserker	266
Lost and Forgotten	The Forgotten, The Lost	106 / 93

Summon: Fabricator summons Guardbots (16–20 HP) during combat.

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Act 3 - Glory: Weak Encounters

Encounter	Monsters	HP
Devoted Sculptor	Devoted Sculptor	162
Turret Operator	Living Shield, Turret Operator	55 / 41
Scrolls of Biting	Scroll of Biting ×3	31–38 each

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General Boss Fighting Strategies

Before every boss fight:

• Use any remaining potions — they reset at the next rest site
• Check your HP and consider whether to rest or upgrade at the campfire
• Review the boss’s mechanics if you’ve seen them before

Universal tips:

• Bosses with multiple phases (Test Subject) require flexible decks that can adapt mid-fight
• Multi-enemy bosses (Kaiser Crab, Queen) reward AoE cards and split-target strategies
• High-HP bosses (Doormaker at 489 HP) need scaling damage, not burst
• Always prioritize learning the boss’s kill condition (e.g., Insatiable’s Sandpit counter) over raw damage